Meetings. In particular when there are disparities as regards their classification as well as … Styrene. (7,12) Dr. Tardiff further commented that the Category C classification “would generally lead EPA to regulate the compound based on … Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). • SIRC is contesting the listing as scientifically unjustified and the result of a flawed process. Acute exposure may also result in gastrointestinal effects. EWG’s Skin Deep rates thousands of personal care product ingredients, culled from ingredient labels on products, based on hazard information pulled from the scientific literature and industry, academic and regulatory databases. The classification of styrene as, “reasonably anticipated to be a human carcinogen,” would have a major impact not only on the individuals employed, but the communities served. Styrene is not classified as a carcinogen by the Japan Industrial Safety and Health Law, but it is considered a “Category 2” based on the former IARC 2B classification. Summary: Styrene is primarily a synthetic chemical. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. A news article in the peer-reviewed journal The Lancet Oncology, … Styrene has been tested for its potential to cause cancer in humans. Most of these products contain styrene linked together in a long chain (polystyrene) as well as unlinked styrene. [44] Learn More OK Probably carcinogenic to humans. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Concurrently, the science of risk assessment and toxicological testing has continued to evolve, and EPA has had to address situations not explicitly discussed in the 1986 guidelines, e.g., children's risk assessment. Human studies are inconclusive on the reproductive and developmental effects of styrene. 1. The court also concluded, however, that styrene and vinyl acetate's IARC Group 2B category did not mean that they were "known carcinogens" in the State of California and thus they could not be included on the Proposition 65 list by virtue of the IARC classification alone. Note however that this classification is based on chronic non-lethal exposure, not on acute exposure. Environmental Protection Agency (EPA), Integrated Risk Information System (IRIS). • SIRC will submit additional studies to … NTP classification: Reasonably anticipated to be a humans carcinogen. P ag e 6 of 9 MSDS -STYRENE 10. Please contact NTP, IARC, or EPA’s IRIS Hotline with questions on cancer and cancer classification. Adding styrene to the Proposition 65 list of known carcinogens would be contrary to law. Succinctly characterizes the toxicologic and adverse health effects information for a hazardous substance. IARC: Possibly carcinogenic to humans. For more information about this message, please visit this page: Agency for Toxic Substances & Disease Registry, Health Effects of Exposure to Substances and Carcinogens, Community Environmental Health Education Presentations, Case Studies in Environmental Medicine (CSEM), Toxicology Curriculum for Communities Trainer's Manual, Compendium of Papers on MRLs and Health Effects, Agency for Toxic Substances and Disease Registry. It's a colorless liquid that evaporates easily and has a sweet smell. The MRL is an estimate of the daily human exposure to a hazardous substance that is likely to be without appreciable risk of adverse, non-cancer health effects over a specified duration of exposure. Contact. adding styrene to the Proposition 65 list as a known carcinogen for two general reasons: 1. Group 2B. It often contains other chemicals that give it a sharp, unpleasant smell. The Japan Society for Occupational Health classifies styrene as a Group 2 reproductive toxicant. NTP: Reasonably anticipated to be a human carcinogen . More . Styrene is released into indoor air from some paints and building materials, such as certain types of insulation, insulated panels, and rubber flooring. Lawsuit to be decided in early 2012. Agents Classified by the IARC Monographs, Volumes 1–128. For this reason, some items on this page will be unavailable. Agency for Toxic Substances and Disease Registry (ATSDR), (June 2012). Styrene is regarded as a "known carcinogen ", especially in case of eye contact, but also in case of skin contact, of ingestion and of inhalation, according to several sources. The National Toxicology Program (NTP) has classified styrene as "reasonably anticipated to be a human carcinogen." Group 1. 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