Participants in the treatment arm of the trial are those who test positive for SARS-COV-2 infection at the time of screening. Bramante et al, Lancet Healthy Longevity, females with DM or obesity, claims data from 50 US5 states: OR mortality 0.759 (0.601, 0.960) by propensity matching; OR 0.785 (0.650, 0.951) by Cox model. All trials on the list are supported by NCI. Levonorgestrel-releasing intrauterine system is a device placed in the uterus that reduces the level of estrogen in the body. Studies show that metformin may influence metabolic and cellular processes that are associated with the development of age-related conditions. Location: 6 locations, This phase I / II trial studies the side effects and best dose of metformin hydrochloride when given together with cisplatin and external beam radiation therapy in treating participants with stage III-IV head and neck squamous cell cancer. While vaccine development for SARS-CoV-2 has been promising, there may be reduced willingness among the public to receive a vaccine developed so quickly. Participants in this arm and group will receive placebo. Clinical trials look at new ways to prevent, detect, or treat disease. Positive laboratory test for active SARS-CoV-2 viral infection based on local laboratory standard (i.e. The TAME (Targeting Aging with Metformin) Trial will establish a clinical trial to provide proof-of-concept that aging can be treated, just as we treat diseases. Eight different companies were represented as sponsors in the trials, with nine studies sponsored by MNCs. Lou et al, Am J Trop Med, adults with diabetes in China, OR for survival: 4.36 (1.22-15.59). Drugs used in chemotherapy, such as docetaxel, carboplatin, trastuzumab, pertuzumab, and pegfilgrastim, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. If certain medical tests, such as an X-ray scan, for example, make you uncomfortable, ask in advance if those or other procedures will be part of the clinical trial. Before diabetes treatments are used to treat patients, their effects must be carefully tested in clinical phases. Lilly posts results of all registered Lilly-sponsored clinical trials. The DPP was a randomized, controlled clinical trial conducted at 27 clinical centers around the United States from 1996 to 2001. Information provided by (Responsible Party): Participants in the PEP cohort of the trial are those who do not test positive for SARS-COV-2 infection at the time of screening but had a close exposure to SARS-CoV-2 infected person (defined by current CDC definition of close contact). Why Should I Register and Submit Results? Giving metformin hydrochloride in addition to treatment with levonorgestrel-releasing intrauterine system may be an effective alternative for patients with atypical endometrial hyperplasia or endometrial cancer who cannot undergo surgery. article SPHK1 Is a Novel Target of Metformin in Ovarian Cancer. The clinical trials on this list are studying Metformin Hydrochloride. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. This is one of the primary outcomes for the stage 1 trial. The discovery of metformin began with the synthesis of galegine-like compounds derived from Gallega officinalis, a plant traditionally employed in Europe as a drug for diabetes treatment for centuries [].In 1950, Stern et al. Reality: Knowing what to expect before you join can help ease anxieties you might have about the trial. Genetic and Rare Diseases Information Center.  (Clinical Trial). But before finding this out they need to know how and why metformin affects prostate cancer. Test if metformin treatment in non-hospitalized adults with SARS-CoV-2 infection can prevent emergency department utilization for Covid-19. As a result, it has become the most widely prescribed antidiabetes drug worldwide. Nelfinavir and bortezomib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT04510194. Metformin hydrochloride is primarily used to treat and prevent type 2 diabetes. Participants in this arm and group will receive the metformin. Estrogen may cause cancer. NCI’s basic information about clinical trials explains the types and phases of trials and how they are carried out. The fully powered trial is a parallel enrolling treatment and post-exposure prophylaxis trial. This is one of the primary outcomes for the stage 1 trial. Talk with your doctor and family members or friends about deciding to join a study. : Estimated Glomerular Filtration Rate (eGFR) of < 45ml/min/1.73 m2, Other kidney disease that in the opinion of the investigator would affect clearance, Electronic medical record history of severe liver disease, Other liver disease that in the opinion of the investigator, would affect metformin clearance, Documented AST or ALT > 3 times the upper limit of normal within 3 months of randomization (if available in electronic medical record), Enrollment in another blinded RCT for COVID, Patients taking these medications: cimetidine, hydroxychloroquine, insulin, sulfonylurea, dolutegravir, patiromer, ranolazine, tafenoquine. The use of metformin hydrochloride may prevent breast cancer. American Kennel Club Canine Health Foundation, Inc. 8051 Arco Corporate Dr. Suite 300 Raleigh, NC 27617 (888)-682-9696. Please remove one or more studies before adding more. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Type 2 diabetes occurs when the pancreas is unable to produce insulin within the body, resulting in hyperglycemia. One of the first cancer clinical trials of a metformin analogue – IM-156, from the American Houston-based biotech Immunomet – is set to start in Korea in the first half of 2018. Location: 20 locations, This randomized phase II trial studies how well chemotherapy with or without metformin hydrochloride work in treating patients with HER2 positive breast cancer that can be removed by surgery. Gordon et al found decreased SARS-CoV-2 and increased cell viability with metformin in vitro. You may want to think about taking part in a clinical trial. Learn more about the study here: Pet owners with pets that meet study […] Location: University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, This phase II pilot trial studies how will metformin hydrochloride works in mitigating the side effects of radioactive iodine treatment in patients with differentiated thyroid cancer. Researchers think that metformin may reduce the risk of getting prostate cancer or may even be able to treat it. Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor), MET-COVID Trial - Metformin for Outpatient Treatment and Post-exposure Prophylaxis (PEP) of COVID-19, Experimental: PEP Cohort - Treatment Group, Placebo Comparator: PEP Cohort - Placebo Group, Experimental: Treatment Arm - Treatment Group, Placebo Comparator: Treatment Arm - Placebo Group, 30 Years to 85 Years   (Adult, Older Adult), Minneapolis, Minnesota, United States, 55455. Inclusion Criteria, Stage 1 Treatment Trial: Exclusion Criteria, Stage 1 Treatment Trial: To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor. You may want to think about taking part in a clinical trial. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Outpatient metformin use has now been associated with lower IL-6, CRP, and neutrophil-lymphocyte ratio in persons with Covid-19. Giving metformin, nelfinavir, and bortezomib may work better in treating patients with multiple myeloma. It is not yet known whether giving metformin hydrochloride together with doxycycline may be a better way in treating patients with localized breast, uterine, or cervical cancer. Metformin may stop the growth of tumor cells by disrupting the energy source within multiple myeloma cells. Metformin, a biguanide derived from the French lilac, has become the preferred first-line therapy for the treatment of type 2 diabetes (1). Metformin hydrochloride is a widely-used type II diabetes drug that may also stop cancer cells from dividing. Outcome is reported as the change in serum concentrations of albumin (g/dL) from baseline to 5 days and baseline to 10 days. Type 1 diabetes —includes studies funded by the NIH or other U.S. Government agencies by Sean McBride, MD, PhD FRAXA Research Foundation is sponsoring a metformin pilot clinical trial to test the safety, tolerability and efficacy of treating cognition, sleep, attention and anxiety in teens and adults with Fragile X. Metformin is an FDA-approved compound with an established safety profile and minimal side effects. Metformin has about 24 times less reported incidents of lactic acidosis compared with phenformin. Metformin use started in France in 1957, but it was not introduced in the United States until 1995, nearly 20 years after the biguanide phenformin was taken off the market because of its risk of lactic acidosis, which was often fatal." ClinicalTrials.gov Identifier: NCT04510194, Interventional 2020 Jul;583(7816):459-468. doi: 10.1038/s41586-020-2286-9. Metformin hydrochloride may help carboplatin, paclitaxel and docetaxel work better by making tumor cells more sensitive to the drugs. Since September 27, 2007, results of Lilly clinical trials have been presented on clinicaltrials.gov for compounds that are approved for use in humans. Outcome is reported as the change in serum concentrations of c-reactive protein (mg/L) from baseline to 5 days and baseline to 10 days. Aims/hypothesis: The aim of this study was to compare the efficacy and safety of once-weekly albiglutide with once-daily insulin glargine (A21Gly,B31Arg,B32Arg human insulin) in patients with type 2 diabetes inadequately controlled on metformin with or without sulfonylurea. A listing of Diabetes Mellitus Type 2 medical research trials actively recruiting patient volunteers. Cariou et al, Diabetologia, adults with diabetes (DM) in France: OR mortality 0.59 (0.42, 0.84), Crouse et al, medrxiv.org adults with DM at Univ of Alabama Birmingham: OR mortality 0.33 (0.13-0.84). Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O'Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Hüttenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O'Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu-Ozturk D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d'Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, García-Sastre A, Shokat KM, Shoichet BK, Krogan NJ. Metformin was most effective in women with a history of gestational diabetes, in people between the ages of 25 and 44, and in people with obesity who had a body mass index of 35 or higher. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Below is a list of selected clinical trials that are currently open and recruiting, but you can expand or narrow your search. A study in 180 patients from across the United States with type 1 diabetes and COVID-19 included 43% […] It may also help doctors understand how well patients respond to treatment. Symptom onset greater than 7 days before randomization (symptoms not required for inclusion). Location: 3 locations, This early phase I trial studies how well metformin hydrochloride works when added to levonorgestrel-releasing intrauterine system in treating patients with atypical endometrial hyperplasia or endometrial cancer who cannot undergo surgery. Drugs used in chemotherapy, such as carboplatin, paclitaxel and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The study will evaluate 3,000 people over a course of six years. Bramante et al. Location: 14 locations, This early phase I trial studies the effects of metformin hydrochloride in participants with malignant solid tumors. The VA IMPACT trial is currently evaluating metformin versus placebo among patients without diabetes and is powered for cardiovascular outcomes. It is not yet known whether giving metformin hydrochloride with chemotherapy will work better in treating patients with breast cancer. article Effect of metformin on the survival of patients with ALL who express high levels of the ABCB1 drug resistance gene. MNCs have played a significant role in the clinical trials of metformin FDCs. The GRADE Study is a pragmatic, unmasked clinical trial that will compare commonly used diabetes medications, when combined with metformin, on glycemia-lowering effectiveness and patient-centered outcomes. Metformin hydrochloride may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving metformin hydrochloride together with combination chemotherapy may kill more tumor cells. This drug is inexpensive, has an excellent safety profile, and can be safely combined with other antidiabetes agents (2). DPP Study Design. What clinical trials for diabetes are open? Clinical trials are an important step in our being able to have new treatments for diabetes and other conditions. Participants in the treatment arm of the trial are those who test positive for SARS-COV-2 infection at the time of screening. Test if metformin treatment in non-hospitalized adults with SARS-CoV-2 disease can prevent Covid-19 disease progression. Bramante et al. 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