Trichloroethylene (TCE) CAS ID #: 79-01-6 Affected Organ Systems: Developmental (effects during periods when organs are developing) , Neurological (Nervous System) Cancer Classification: EPA: Carcinogenic to humans, IARC: Carcinogenic to humans (evidence for cancer is based on kidney cancer, limited evidence for non-Hodgkin lymphoma and liver cancer, as well as, 窶ヲ TCE exposure may cause kidney cancer and increase the risk of lymphoma and liver cancer. Based on this TCE is carcinogenic to humans by all routes of exposure and poses a potential human health hazard for noncancer toxicity to the central nervous system, kidney, liver, immune system, male reproductive system, and the developing Even though recent regulation mandates restricted utilization of TCE, its use is not completely prohibited, especially in industrial and manufacturing processes. In response to the heightened awareness of environmental toxins such as TCE and the role they may be playing in childhood disease, in 2007, Senator Barack Obama proposed S1068, co-sponsored by Hillary Clinton and John Kerry. If you believe you have any of these, don't hesitate to research further and file a claim for VA health窶ヲ The trichloroethylene health effects of chronic exposure paint a darker picture. 1992) and develop-mental toxicity (e.g., Johnson et al. Exposures of this degree would usually only be found in occupational settings. Trichloroethylene (TCE) is a chemical used to make refrigerants and as a metal degreaser. 2009 ), and reproductive systems and developing embryo/fetus ( NRC 2006 ). This link has been most clearly seen in case studies where expectant mothers drank water from wells and municipal water supplies contaminated with TCE. Health effects similar to those described below are unlikely to be observed in the general public. A broad and complex range of relevant information for assessing human health effects of TCE is available. Reproductive Health Effects: A number of studies have suggested a linkage between TCE exposure and birth defects. TCE HEALTH EFFECTS TCE ASSOCIATED WITH ADVERSE HEALTH The medically conservative federal Agency for Toxic Substances and Disease Registry (ATSDR) has found that TCE is associated with adverse health effects, but it stopped short of concluding a causal relationship. TCE may cause adverse health effects following exposure via inhalation, ingestion, dermal or eye contact. TCE exposure can be associated with several adverse health effects, including neurotoxicity, immunotoxicity, developmental toxicity, liver toxicity, kidney toxicity, endocrine effects, and several forms of 窶ヲ Previous reviews have found TCE to adversely affect the central nervous system ( Bale et al. The public Trichloroethylene (TCE) is a man-made chemical that can be a liquid or gas. Trichloroethylene (TCE) is one of the most common ground water contaminants in USA. health effects of TCE is less clear, although similarities have been observed between TCE and its oxidative metabolites in the respiratory tract (e.g., Odum et al. Health Effects of TCE Immune effects have been identified as the most sensitive non-cancer health effect caused by exposure to TCE. Trichloroethylene (TCE) is a chemical used primarily as an industrial degreaser and solvent. Google TCE and EPA 2011. In addition to the conditions listed in the 2012 Camp Lejeune law regarding contamination and healthcare, ATSDR studies also reveal these observed health effects due to contamination. TCE exposure is associated with several adverse health effects, including neurotoxicity, immunotoxicity, developmental toxicity, liver toxicity, kidney toxicity, endocrine effects, and several forms of cancer. "The health risks of TCE have been studied extensively. Trichloroethylene (CICH=CCl 2) is a colorless liquid with a chloroform-like odor.Trichloroethylene may cause irritation to the eyes and skin. TCE was the primary contaminant measured and was present at relatively high concentrations; however, the specific role of TCE in inducing neurobehavioral effects cannot be evaluated. contaminated indoor air. The report has raised more concerns about the health effects of TCE. Acute effects are those that occur after short-term exposure (e.g. Objectives: We summarized the key findings and scientific issues regarding the human health effects of TCE in the U.S. EPA窶冱 toxicological review. concentrations in It may be found in contaminated soil or water near military bases and in some commercial and household cleaning products. An updated Public Health Goal (PHG) of 1.7 parts per billion (ppb) is established for trichloroethylene (TCE) in drinking water, which is derived from the same studies as the existing PHG of 0.8 ppb, published in 1999. It is a nonflammable colorless liquid with a sweet odor similar to ether or chloroform. Look for a 1200 page report on TCE and its health effects. In particular, an association between TCE (as well other organic solvents) and systemic sclerosis has been replicated by many studies, and this association has recently been reviewed [35] , [36] . minutes, a few days) to very high concentrations of TCE (e.g. Studies of human populations (epidemiologic studies) suggest Studies of human populations (epidemiologic studies) suggest that trichloroethylene may also affect human health, but less is known about the exposures needed to induce Although there are many health effects described for TCE, especially for acute exposures to high concentrations, the levels of TCE in the Bishop Street Community are not expected to result in the acute effects described for TCE. The following health effects may occur immediately or shortly after inhaling air that contains very high levels of TCE (more than 50,000 ppbV). At the time of the 1985 sampling, the highest TCE levels measured at the LWD wells were in the range of 50窶�60 ppb ( Camp, Dresser and Mckee 1991 ). Exposure to high concentrations can cause dizziness, headaches, sleepiness, confusion, nausea, unconsciousness, liver damage, and even death. TCE Health Effects 窶「 Acute effects: 窶� Occur at levels starting from 540,000 ホシg/m3 (EPA, 2001) 窶� Effects include sleepiness/dizziness, headache, irritation, poor coordination, difficulty concentrating 窶� 窶ヲ The possible health effects from exposure to TCE depend on the levels of TCE in the air or water, the length of the exposure, and whether or not sensitive individuals are exposed. 2000b ), immune system ( Cooper et al. health effects, including cancer. Q: What health effects are seen in animals from TCE exposure? An increased risk of developing autoimmune diseases is one of the most consistently reported adverse health effects of TCE . According to ATSDR, chronic exposure to the levels of TCE listed above can precipitate the following serious health problems that may not go away: A Public Health Goal (PHG) of 0.0008 mg/L (0.8 ppb) was developed for trichloroethylene (TCE) in drinking water. A: Results of animal studies showed that TCE may cause liver, kidney, or lung cancer. The EPA evaluated 54 uses of the chemical, including manufacturing, processing, and 窶ヲ What remains in the body is changed by the liver to other chemicals that are quickly eliminated in the urine. The U.S. Environmental Protection Agency (EPA) sponsored a "state of the science" review of the health effects associated with exposure to trichloroethylene. H Trichloroethylene (TCE) - 1 of 7 Toxicological Summary for: Trichloroethylene (TCE) CAS: 79-01-6 Health Based Guidance for Water ealth Risk Assessment Unit, Environmental Health Division 651-201-4899 Adopted as Rule Health Effects Absorption Studies indicate that 40 to 70 percent of TCE is absorbed by inhalation exposure, which is the most common TCE exposure route. TCE Health Effects TCE is quickly eliminated from the body by breathing, whether exposed occurs through breathing or oral ingestion, find both ATSDR (2014) and EPA (2011). TCE is carcinogenic and associated with adverse neurological, developmental, and immunological effects. [67] Breathing TCE vapor, especially at high levels or over long periods of time, can cause negative health effects. Health risks can be categorized into acute effects and chronic/sub-chronic effects. 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