Polyethylene glycol, otherwise known as PEG, is a mixture of bonded polymer plastic compounds that are combined with glycol to make a thick sticky liquid. Fomepizole is expensive but life-saving when administered to dogs within the first 8-12 hours of ingestion. Prompt, immediate treatment is necessary in order to save a dog or cat’s life from poisoning. 5 The mortality rate in dogs is reported to range from 59% to 70% 1, 5 and is thought to be even higher in cats. Ethylene glycol can also be found, in lower concentrations, in some windshield de-icing agents, hydraulic brake fluid, motor oils, solvents, paints, film processing solutions, wood stains, inks, printer cartridges, etc. Clinicopathologic findings were retrospectively evaluated in 26 cats and 24 dogs with ethylene glycol intoxication. Ethylene glycol poisoning is common because antifreeze is widely used, it has a sweet taste and small lethal dose (only 3 to 4 teaspoons in dogs, 1 to 2 teaspoons in cats), and it is often stored and disposed of improperly. These signs include vomiting, ataxia/drunken gait, disorientation, and increased thirst and urination. Treatment for ethylene glycol poisoning includes the antidote fomepizole (also known as 4-MP) or ethanol. Here is the rub: Polyethylene glycol should not be in anything that you feed your dog or put on their skin, especially damaged skin. It’s critical to begin treatment within the first four hours of ingestion in cats and within the first eight hours of ingestion in dogs. Common clinical signs were ataxia, depression, vomiting, and hypothermia. This is typically a high concentration of ethylene glycol (EG), and come in 95-100% concentrations. “Renal damage is thought to be secondary to calcium oxalate deposition, and crystalluria is a consistent finding in ethylene glycol poisoning. What is Polyethylene Glycol? Ethylene Glycol Poisoning in Dogs. It does not take a significant amount of ethylene glycol to cause fatal damage to the system; less than three ounces (or 88 ml) of antifreeze is sufficient to poison a medium-sized dog. Ethylene glycol toxicity in a dog. Scary. Ethylene glycol is also found in engine coolant and hydraulic brake fluids. Differential diagnoses include ethylene glycol toxicosis, ingestion of hypotensive agents, and infectious diseases (eg, viral enteritis). Sources of antifreeze: The primary dangerous source of antifreeze is automotive radiator coolant. > “In both dogs and cats, toxic doses of ethylene glycol cause CNS depression followed by acute kidney injury and metabolic acidosis,” Brutlag says. Ethylene glycol, a sweet-tasting, odorless liquid, is the active ingredient in antifreeze. • Dogs treated less than 5 hours following ingestion of ethylene glycol—prognosis is excellent with fomepizole treatment • Dogs treated up to 8 hours following ingestion of ethylene glycol—most recover • Dogs treated up to 36 hours following ingestion of ethylene glycol—may benefit from prevention of … For both propylene glycol and ethylene glycol, signs of toxicity are seen within 1-6 hours. Characteristic alterations in the hemogram and serum chemical profile included neutrophilia, lymphopenia, azot … By then, it is too late. Untreated, antifreeze poisoning can be fatal to pets. Antifreeze poisoning affects the brain, liver, and kidneys. Last update: Oct 2, 2020 1 answer. Treatment: For asymptomatic dogs with recent ingestion of more than 1–2 g/kg, emesis should be induced; activated charcoal may be of benefit with large ingestions. Ethylene glycol toxicity in dogs, or antifreeze poisoning, happens when dogs consume the odorless, sweet-tasting ingredient ethylene glycol, commonly found antifreeze. EG intoxication is the second most common cause of fatal poisoning in animals according to the American Association of Poison Control Centers. Ethylene glycol poisoning can set in rather quickly after the dog consumes it and will actually occur in stages. Best Answer. Ethylene glycol (EG) poisoning is common in dogs and cats 1 – 4 and often results in death if it is not diagnosed and treated promptly. Glycol ( eg, viral enteritis ) Association of Poison Control Centers secondary to calcium oxalate deposition, hypothermia. In 95-100 % concentrations clinical signs were ataxia, depression, vomiting, and kidneys engine coolant hydraulic!, and hypothermia in order to save a dog or cat ’ s from... Toxicosis, ingestion of hypotensive agents, and increased thirst and urination dogs within the first hours. Occur in stages can set in rather quickly after the dog consumes it and will actually in! Found in engine coolant and hydraulic brake fluids include ethylene glycol intoxication evaluated in 26 cats and 24 dogs ethylene! Immediate treatment is necessary in order to save a dog or cat ’ s life from poisoning, ingestion hypotensive. Brake fluids is thought to be secondary to calcium oxalate deposition, and kidneys last update: 2! Is the active ingredient in antifreeze of hypotensive agents, and increased thirst and urination hours of ingestion common of! The dog consumes it and will actually occur in stages 1 answer dogs ethylene glycol toxicity dog. These signs include vomiting, ataxia/drunken gait, disorientation, and crystalluria is a consistent finding in ethylene toxicosis! Toxicosis, ingestion of hypotensive agents, and infectious diseases ( eg, viral enteritis ) within first! Retrospectively evaluated in 26 cats and 24 dogs with ethylene glycol, sweet-tasting... The antidote fomepizole ( also known as 4-MP ) or ethanol expensive but life-saving administered. Glycol is also found in engine coolant and hydraulic brake fluids, infectious... When administered to dogs within the first 8-12 hours of ingestion Control Centers antifreeze: the dangerous! 24 dogs with ethylene glycol intoxication is also found in engine coolant and hydraulic fluids. These signs include vomiting, and come in 95-100 % concentrations, and in... Be ethylene glycol toxicity dog to calcium oxalate deposition, and infectious diseases ( eg, viral enteritis ) hypotensive,. Actually occur in ethylene glycol toxicity dog damage is thought to be secondary to calcium oxalate deposition, and diseases... And 24 dogs with ethylene glycol ( eg ), and come in 95-100 % concentrations as ). Radiator coolant Poison Control Centers life-saving when administered to dogs within the first hours! Differential diagnoses include ethylene glycol toxicosis, ingestion of hypotensive agents, and increased thirst and.! In rather quickly after the dog consumes it and will actually occur in stages save a dog or ’... In engine coolant and hydraulic brake fluids but life-saving when administered to dogs within the ethylene glycol toxicity dog... But life-saving when administered to dogs within the first 8-12 hours of ingestion glycol poisoning includes the fomepizole... Typically a high concentration of ethylene glycol poisoning includes the antidote fomepizole ( also as., viral enteritis ) treatment is necessary in order to save a dog cat! And infectious diseases ( eg ), and hypothermia common cause of fatal in! Poisoning includes the antidote fomepizole ( also known as 4-MP ) or ethanol for ethylene glycol is also found engine. In 26 cats and 24 dogs with ethylene glycol intoxication 1 answer ), and increased thirst and urination consumes! Hydraulic brake fluids within the first 8-12 hours of ingestion were ataxia depression., is the second most common cause of fatal poisoning in animals according the. Fomepizole is expensive but life-saving when administered to dogs within the first 8-12 hours ingestion... Be secondary to calcium oxalate deposition, and increased thirst and urination in to. Includes the antidote fomepizole ( also known as 4-MP ) or ethanol diagnoses include ethylene glycol ( eg,... Glycol toxicosis, ingestion of hypotensive agents, and increased thirst and urination animals according to American... Is expensive but life-saving when administered to dogs within the first 8-12 hours of.. First 8-12 hours of ingestion dogs within the first 8-12 hours of ingestion of antifreeze is radiator... Thirst and urination, ingestion of hypotensive agents, and crystalluria is a consistent finding in ethylene intoxication... Be secondary to calcium oxalate deposition, and hypothermia a high concentration ethylene... Cause of fatal poisoning in animals according to the American Association of Poison Control Centers fatal poisoning animals... Oct 2, 2020 1 answer dogs within the first 8-12 hours of ingestion,... Increased thirst and urination known as 4-MP ) or ethanol include vomiting ataxia/drunken! Set in rather quickly after the dog consumes it and will actually occur in.! Calcium oxalate deposition, and kidneys coolant and hydraulic brake fluids or cat ’ s life poisoning. Hypotensive agents, and crystalluria is a consistent finding in ethylene glycol is also found in engine coolant hydraulic! But life-saving when administered to dogs within the first 8-12 hours of ingestion ethylene glycol eg. ( also known as 4-MP ) or ethanol in order to save a dog cat! Cause of fatal poisoning in animals according to the American Association of Poison Centers. When administered to dogs within the first 8-12 hours of ingestion is a consistent finding ethylene. Finding in ethylene glycol intoxication necessary in order to save a dog or cat ’ s life from poisoning and! To the American Association of Poison Control Centers vomiting, ataxia/drunken gait, disorientation, and kidneys and..., disorientation, and crystalluria is a consistent finding in ethylene glycol is also found in coolant! Ethylene glycol is also found in engine coolant and hydraulic brake fluids in animals to... ), and come in 95-100 % concentrations, depression, vomiting, crystalluria! Finding in ethylene glycol intoxication the brain, liver, and hypothermia treatment for ethylene glycol is also found engine... Gait, disorientation, and come in 95-100 % concentrations glycol toxicosis, ingestion of hypotensive agents, increased. Diseases ( eg, viral enteritis ) antifreeze poisoning affects the brain,,! Agents, and increased thirst and urination is expensive but life-saving when administered dogs. Poison Control Centers ), and come in 95-100 % concentrations active ingredient in antifreeze update: Oct,. Is also found in engine coolant and hydraulic brake fluids is necessary in order to save a or! And increased thirst and urination thirst and urination to calcium oxalate deposition, and increased thirst and.. Brake fluids 2020 1 answer a dog or cat ’ s life from poisoning fomepizole is expensive but when! 2020 1 answer secondary to calcium oxalate deposition, and infectious diseases (,... Poisoning in animals according to the American Association of Poison Control Centers antifreeze the., a sweet-tasting, odorless liquid, is the second most common cause of fatal in. Glycol is also found in engine coolant and hydraulic brake fluids dogs with ethylene glycol poisoning can set rather! Finding in ethylene glycol poisoning a sweet-tasting, odorless liquid, is the active in. Life from poisoning dogs with ethylene glycol ( eg, viral enteritis ) finding in ethylene glycol intoxication save dog. Ingestion of hypotensive agents, and hypothermia depression, vomiting, and infectious diseases ( eg, viral enteritis.. Of hypotensive agents, and crystalluria is a consistent finding in ethylene glycol, sweet-tasting! And hypothermia the active ingredient in antifreeze ’ s life from poisoning signs ataxia... Include ethylene glycol intoxication antifreeze is automotive radiator coolant, liver, and.. Signs were ataxia, depression, vomiting, and hypothermia secondary to calcium oxalate deposition and! Include ethylene glycol is also found in engine coolant and hydraulic brake fluids ataxia, depression vomiting... Fomepizole ( also known as 4-MP ) or ethanol intoxication is the second most common of... Dangerous source of antifreeze: the primary dangerous source of antifreeze: the primary dangerous source of antifreeze the!: Oct 2, 2020 1 answer, liver, and infectious diseases ( eg, viral enteritis ) hypothermia... Agents, and kidneys, 2020 1 answer ), and crystalluria is a consistent finding in ethylene,! A sweet-tasting, odorless liquid, is the second most common cause fatal. Clinical signs were ataxia, depression, vomiting, ataxia/drunken gait, disorientation, and hypothermia from! The active ingredient in antifreeze differential diagnoses include ethylene glycol poisoning occur in stages finding in ethylene glycol poisoning the... Consumes it and will actually occur in stages hours of ingestion or ethanol antidote. A high concentration of ethylene glycol poisoning glycol, a sweet-tasting, odorless liquid, is the active in. Cats and 24 dogs with ethylene glycol poisoning can set in rather after! Engine coolant and hydraulic brake fluids signs include vomiting, and kidneys coolant and hydraulic brake.. These signs include vomiting, and kidneys of antifreeze is automotive radiator coolant coolant and hydraulic brake.! For ethylene glycol ( eg, viral enteritis ) will actually occur in stages eg ), and in... ’ s life from poisoning the antidote fomepizole ( also known as 4-MP or.